Article
A katG S315T or an ahpC promoter mutation mediate Mycobacterium tuberculosis resistance to 2-thiophen carboxylic acid hydrazide, an inhibitor resembling the anti-tubercular drugs Isoniazid and Ethionamide.
Tuberculosis (Edinburgh, Scotland) - 1 Sept 2018
Franceschelli Jorgelina J, Belardinelli Juan M, Tong Ping, Loftus Brendan, Recio-Balsells Alejandro, Labadié Guillermo R, Gordon Stephen V, Morbidoni Hector R
Abstract excerpt
Clinical isolates of Mycobacterium tuberculosis and Mycobacterium bovis are differentially susceptible to 2-Thiophen Hydrazide (TCH); however its mechanism of action or the reasons for that difference are unknown. We report herein that under our experimental conditions, TCH inhibits M. tuberculosis in solid but not in liquid medium, and that in spite of resembling Isoniazid and Ethionamide, it does not affect...
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