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Article

Phenotypic characterization of pncA mutants of Mycobacterium tuberculosis.

Antimicrobial agents and chemotherapy - 1 Sept 2000

Morlock G P, Crawford J T, Butler W R, Brim S E, Sikes D, Mazurek G H, Woodley C L, Cooksey R C

Abstract excerpt

We examined the correlation of mutations in the pyrazinamidase (PZase) gene (pncA) with the pyrazinamide (PZA) resistance phenotype with 60 Mycobacterium tuberculosis isolates. PZase activity was determined by the method of Wayne (L. G. Wayne, Am. Rev. Respir. Dis. 109:147-151, 1974), and the entire pncA nucleotide sequence, including the 74 bp upstream of the start codon, was determined. PZA susceptibility...

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Identifiers

PMID: 10952570
DOI: 10.1128/AAC.44.9.2291-2295.2000
PMCID: PMC90060

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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