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Article

Ethionamide activation and sensitivity in multidrug-resistant Mycobacterium tuberculosis.

Proceedings of the National Academy of Sciences of the United States of America - 15 Aug 2000

DeBarber A E, Mdluli K, Bosman M, Bekker L G, Barry C E

Abstract excerpt

Ethionamide (ETA) is an important component of second-line therapy for the treatment of multidrug-resistant tuberculosis. Synthesis of radiolabeled ETA and an examination of drug metabolites formed by whole cells of Mycobacterium tuberculosis (MTb) have allowed us to demonstrate that ETA is activated by S-oxidation before interacting with its cellular target. ETA is metabolized by MTb to a 4-pyridylmethanol...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 10944230
DOI: 10.1073/pnas.97.17.9677
PMCID: PMC16924

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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