Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phenotypic Models of CAR T-Cell Activation Elucidate the Pivotal Regulatory Role of CAR Downmodulation.

Molecular cancer therapeutics - 1 May 2021

Greenman Raanan, Pizem Yoav, Haus-Cohen Maya, Horev Guy, Denkberg Galit, Shen-Orr Shai, Rubinstein Jacob, Reiter Yoram

Abstract excerpt

Adoptive cell immunotherapy with chimeric antigen receptor (CAR) showed limited potency in solid tumors, despite durable remissions for hematopoietic malignancies. Therefore, an investigation of ways to enhance the efficacy of CARs' antitumor response has been engaged upon. We previously examined the interplay between the biophysical parameters of CAR binding (i.e., affinity, avidity, and antigen density), as...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mice
Share to Models, Theoretical

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phenotype

Share to Receptors, Chimeric Antigen

Share to T-Lymphocytes

Source

Identifiers

PMID: 33649103
DOI: 10.1158/1535-7163.MCT-19-1110

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenotypic Models of CAR T-Cell Activation Elucidate the Pivotal Regulatory Role of CAR Downmodulation.PMID 33649103Read ↗

Chimeric antigen receptor signaling: Functional consequences and design implicationsSemantic proximity Read ↗

Integrating binding affinity and tonic signaling enables a rational CAR design for augmented T cell functionSemantic proximity Read ↗

Dissecting the role of CAR signaling architectures on T cell activation and persistence using pooled screens and single-cell sequencingSemantic proximity Read ↗

T Cell Activation Machinery: Form and Function in Natural and Engineered Immune ReceptorsSemantic proximity Read ↗

Precise engineering of chimeric antigen receptor expression levels defines T cell identity and functionSemantic proximity Read ↗

Mechanisms of Resistance to CAR-T cell Immunotherapy: Insights from a Mathematical ModelSemantic proximity Read ↗

Modeling Patient-Specific CAR-T Cell Dynamics: Multiphasic Kinetics via Phenotypic DifferentiationSemantic proximity Read ↗

Strategies to Address Chimeric Antigen Receptor Tonic SignalingSemantic proximity Read ↗

Membrane positioning across antigen-induced synaptic contacts tunes CAR-T cell signaling and effector responsesSemantic proximity Read ↗

Rational Tuning of CAR Tonic Signaling Yields Superior T-Cell Therapy for CancerSemantic proximity Read ↗

Antigen experience history directs distinct functional states of CD8+ CAR T cells during the anti-leukemia responseSemantic proximity Read ↗

Engineering Cytoplasmic Signaling of CD28ζ CARs for Improved Therapeutic FunctionsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.