Article

The landscape of MHC-presented phosphopeptides yields actionable shared tumor antigens for cancer immunotherapy across multiple HLA alleles

2023-02-09

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Certain phosphorylated peptides are differentially presented by MHC molecules on cancer cells characterized by aberrant phosphorylation. Phosphopeptides presented in complex with the human leukocyte antigen HLA-A*02:01 provide a stability advantage over their nonphosphorylated counterparts. This stability is thought to contribute to enhanced immunogenicity. Whether tumor-ass...

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Literature Corpus work: 6bbc302a-ccef-55d3-a5f1-3dd54585e7b4
DOI: 10.1101/2023.02.08.527552

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