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Article

The heterochronic gene Lin28 regulates amphibian metamorphosis through disturbance of thyroid hormone function

28 Mar 2017

Abstract excerpt

Metamorphosis is a classic example of developmental transition, which involves important morphological and physiological changes that prepare the organism for the adult life. It has been very well established that amphibian metamorphosis is mainly controlled by Thyroid Hormone (TH). Here, we show that the heterochronic gene Lin28 is downregulated during Xenopus laevis metamorphosis. Lin28 overexpression before...

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PMID: 28359807
DOI: 10.1016/j.ydbio.2017.03.026

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