Article
Tripeptide binding in a proton-dependent oligopeptide transporter.
FEBS letters - 1 Oct 2018
Martinez Molledo Maria, Quistgaard Esben M, Löw Christian
Abstract excerpt
Proton-dependent oligopeptide transporters (POTs) are important for the uptake of di-/tripeptides in many organisms and for drug transport in humans. The binding mode of dipeptides has been well described. However, it is still debated how tripeptides are recognized. Here, we show that tripeptides of the sequence Phe-Ala-Xxx bind with similar affinities as dipeptides to the POT transporter from Streptococcus...
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