Article
Extracellular loop 4 of the proline transporter PutP controls the periplasmic entrance to ligand binding sites.
Structure (London, England : 1993) - 6 May 2014
Raba Michael, Dunkel Sabrina, Hilger Daniel, Lipiszko Kamila, Polyhach Yevhen, Jeschke Gunnar, Bracher Susanne, Klare Johann P, Quick Matthias, Jung Heinrich, Steinhoff Heinz-Jürgen
Abstract excerpt
The Na(+)/proline symporter (PutP), like several other Na(+)-coupled symporters, belongs to the so-called LeuT-fold structural family, which features ten core transmembrane domains (cTMs) connected by extra- and intracellular loops. The role of these loops has been discussed in context with the gating function in the alternating access model of secondary active transport processes. Here we report the complete...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.