Article
High GATA2 expression is a poor prognostic marker in pediatric acute myeloid leukemia.
Blood - 6 Sept 2012
Luesink Maaike, Hollink Iris H I M, van der Velden Vincent H J, Knops Ruth H J N, Boezeman Jan B M, de Haas Valérie, Trka Jan, Baruchel Andre, Reinhardt Dirk, van der Reijden Bert A, van den Heuvel-Eibrink Marry M, Zwaan C Michel, Jansen Joop H
Abstract excerpt
In acute myeloid leukemia (AML), aberrant expression and mutations of transcription factors have been correlated with disease outcome. In the present study, we performed expression and mutation screening of GATA2, which is an essential transcription factor for regulation of myeloid lineage determination, in de novo pediatric AML patients. GATA2 mutations were detected in 5 of 230 patients, representing a...
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