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GATA2mutant variant allele frequency may reflect prognosis in Chinese adult patients with de novo cytogenetically normal acute myeloid leukemia.

Biomolecules & biomedicine - 27 Feb 2024

Ren Huanying, Hong Minglin, Feng Jingyi, Hao Zhuanghui, Chen Xian, Liang Fengting, Wei Wei, Liang Xuelan, Wang Hongwei, Chen Xiuhua

Abstract excerpt

Exploration of variant allele frequency (VAF) of GATA2 mutations (GATA2mut) provides insights into acute myeloid leukemia (AML) prognosis. In this study, we analyzed GATA2mut and co-mutations in 166 Chinese patients with cytogenetically normal AML. This was done through targeted next-generation sequencing of 34 genes associated with myeloid leukemia. GATA2mut was identified in 17 (10%) patients being...

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Identifiers

PMID: 38416121
DOI: 10.17305/bb.2024.10244
PMCID: PMC11293240

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