Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

GATA2 Mutations Predict Poor Prognosis in Transplanted Myeloid Neoplasms.

Cancer medicine - 1 May 2026

Zhang Xian, Wang Bingjie, Dong Yujun, Wang Qingya, Wang Qian, Zhu Jialin, Wang Qingyun, Han Na, Li Yuan

Abstract excerpt

BACKGROUND: GATA binding protein 2 (GATA2) plays a crucial role in the differentiation, proliferation, and maintenance of hematopoietic stem cells (HSCs). GATA2 mutations have been identified in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS), but the impact of somatic GATA2 mutations on prognosis remains controversial, especially on patients who undergo allogeneic hematopoietic stem cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Case-Control Studies
Share to GATA2 Transcription Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hematopoietic Stem Cell Transplantation

Share to Leukemia, Myeloid, Acute

Share to Myelodysplastic Syndromes

Share to Prognosis

Share to Transplantation, Homologous

Share to Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 42050760
DOI: 10.1002/cam4.71883
PMCID: PMC13124652

Genes

GATA2
WT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

GATA2 Mutations Predict Poor Prognosis in Transplanted Myeloid Neoplasms.PMID 42050760Read ↗

The Clinical Spectrum, Diagnosis, and Management of GATA2 DeficiencySemantic proximity Read ↗

Comparison of Outcomes of Myeloablative Allogeneic Stem Cell Transplantation for Pediatric Patients with Bone Marrow Failure, Myelodysplastic Syndrome and Acute Myeloid Leukemia with and without Germline GATA2 MutationsSemantic proximity Read ↗

GATA2 zinc finger 1 mutations are associated with distinct clinico-biological features and outcomes different from GATA2 zinc finger 2 mutations in adult acute myeloid leukemia.Semantic proximity Read ↗

Successful umbilical cord blood hematopoietic stem cell transplantation in pediatric patients with MDS/AML associated with underlying GATA2 mutations: two case reports and review of literature.Semantic proximity Read ↗

Prognostic significance of GATA2 in patients with MDS/AML: a systematic review and meta-analysis.Semantic proximity Read ↗

Donor-derived MDS/AML in families with germline GATA2 mutationSemantic proximity Read ↗

GATA2 Deficiency: Predisposition to Myeloid Malignancy and Hematopoietic Cell Transplantation.Semantic proximity Read ↗

GATA2 deficiency and related myeloid neoplasms.Semantic proximity Read ↗

Long‐term outcome after allogeneic stem cell transplantation for GATA2 deficiency: An analysis of 67 adults and children from France and BelgiumSemantic proximity Read ↗

GATA2 rs2335052 and GATA2 rs78245253 single-nucleotide polymorphisms in Chinese patients with acute myelocytic leukemia.Semantic proximity Read ↗

WT1 gene mutations impact post-transplant relapse in myelodysplastic syndrome with excess blasts 2 patients.Semantic proximity Read ↗

Heritable GATA2 mutations associated with familial myelodysplastic syndrome and acute myeloid leukemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.