Article
Increased expression of Grainyhead-like-3 rescues spina bifida in a folate-resistant mouse model.
Human molecular genetics - 1 Nov 2007
Gustavsson Peter, Greene Nicholas D E, Lad Dina, Pauws Erwin, de Castro Sandra C P, Stanier Philip, Copp Andrew J
Abstract excerpt
Neural tube defects (NTDs), such as spina bifida, are common and severe birth defects in humans but the underlying causes are poorly understood. The pathogenesis and etiology of spina bifida in the curly tail mouse closely resemble defects in humans, providing a well-characterized model of NTDs. Grainyhead-like-3 (Grhl3), which encodes a transcription factor, was recently identified as a candidate gene for curly...
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