Article
Inositol- and folate-resistant neural tube defects in mice lacking the epithelial-specific factor Grhl-3.
Nature medicine - 1 Dec 2003
Ting Stephen B, Wilanowski Tomasz, Auden Alana, Hall Mark, Voss Anne K, Thomas Tim, Parekh Vishwas, Cunningham John M, Jane Stephen M
Abstract excerpt
The neural tube defects (NTDs) spina bifida and anencephaly are widely prevalent severe birth defects. The mouse mutant curly tail (ct/ct) has served as a model of NTDs for 50 years, even though the responsible genetic defect remained unrecognized. Here we show by gene targeting, mapping and genetic complementation studies that a mouse homolog of the Drosophila grainyhead (grh) gene, grainyhead-like-3 (Grhl3), is...
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