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Detecting past and ongoing natural selection among ethnically Tibetan women at high altitude in Nepal

6 Sept 2018

Abstract excerpt

Adaptive evolution in humans has rarely been characterized for its whole set of components, i.e. selective pressure, adaptive phenotype, beneficial alleles and realized fitness differential. We combined approaches for detecting polygenic adaptations and for mapping the genetic bases of physiological and fertility phenotypes in approximately 1000 indigenous ethnically Tibetan women from Nepal, adapted to high...

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PMID: 30188897
DOI: 10.1371/journal.pgen.1007650

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