Article
On the origin of Tibetans and their genetic basis in adapting high-altitude environments.
PloS one - 28 Feb 2011
Wang Binbin, Zhang Yong-Biao, Zhang Feng, Lin Hongbin, Wang Xumin, Wan Ning, Ye Zhenqing, Weng Haiyu, Zhang Lili, Li Xin, Yan Jiangwei, Wang Panpan, Wu Tingting, Cheng Longfei, Wang Jing, Wang Duen-Mei, Ma Xu, Yu Jun
Abstract excerpt
Since their arrival in the Tibetan Plateau during the Neolithic Age, Tibetans have been well-adapted to extreme environmental conditions and possess genetic variation that reflect their living environment and migratory history. To investigate the origin of Tibetans and the genetic basis of adaptation in a rigorous environment, we genotyped 30 Tibetan individuals with more than one million SNP markers. Our...
Topics
- Adaptation, Biological
- Altitude
- Altitude Sickness
- Asian People
- Cell Line, Transformed
- Environment
- Female
- Genetic Variation
- Genetics, Population
- Humans
- Linkage Disequilibrium
- Male
- Polymorphism, Single Nucleotide