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Article

Huntingtin N17 domain is a reactive oxygen species sensor regulating huntingtin phosphorylation and localization.

Human molecular genetics - 15 Sept 2016

DiGiovanni Laura F, Mocle Andrew J, Xia Jianrun, Truant Ray

Abstract excerpt

The N17 domain of the huntingtin protein is post-translationally modified and is the master regulator of huntingtin intracellular localization. In Huntington's disease (HD), mutant huntingtin is hypo-phosphorylated at serines 13 and 16 within N17, and increasing N17 phosphorylation has been shown to be protective in HD mouse models. Thus, N17 phosphorylation is defined as a sub-target of huntingtin for potential...

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Identifiers

PMID: 27466181
DOI: 10.1093/hmg/ddw234
PMCID: PMC5291230

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