Polymorphism rs3819102 in thymidylate synthase and environmental factors: effects on lung cancer in Chinese population.

doi:10.1016/j.currproblcancer.2018.07.005

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Polymorphism rs3819102 in thymidylate synthase and environmental factors: effects on lung cancer in Chinese population.

Current problems in cancer - 1 Feb 2019

Feng Wei, Guo Xianling, Huang Haidong, Xu Chang, Li Yutao, Guo Shicheng, Zhao Zhenghong, Li Qiang, Lu Daru, Jin Li, Wang Jiucun, Jiang Gengxi, Wu Junjie

Abstract excerpt

PURPOSE: Lung cancer is the leading cause of cancer death worldwide, and the predominant risk factor for its development is smoking. Thymidylate synthase (TYMS) is a key enzyme in DNA synthesis that catalyzes the conversion of deoxyuridine monophosphate to dTMP. Rs931794, a single nucleotide polymorphism located in the TYMS gene, was suggested to be associated with cancer risk. METHODS: To analyze the interaction...

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PMID: 30180988
DOI: 10.1016/j.currproblcancer.2018.07.005

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