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Influence of polymorphisms in MTHFR 677 C→T, TYMS 3R→2R and MTR 2756 A→G on NSCLC risk and response to platinum-based chemotherapy in advanced NSCLC.

Pharmacogenomics - 1 Jun 2011

Cui Lian-Hua, Yu Zhuang, Zhang Ting-Ting, Shin Min-Ho, Kim Hee-Nam, Choi Jin-Su

Abstract excerpt

AIMS: Genetic factors may contribute to individual differences in cancer susceptibility, drug efficacy and toxicity. This study was designed to investigate the effects of the polymorphisms of methylenetetrahydrofolate reductase 677 C→T (MTHFR 677 C→T), thymidylate synthase (TYMS 3R→2R),and methionine synthase 2756 A→G (MTR 2756 A→G) on the risk of lung cancer and response to platinum-based chemotherapy in...

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Share to 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
Share to Antineoplastic Combined Chemotherapy Protocols

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Source

Identifiers

PMID: 21605004
DOI: 10.2217/pgs.11.27

Genes

MTHFR
MTR
TYMS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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