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TPX2/Aurora kinase A signaling as a potential therapeutic target in genomically unstable cancer cells

3 Sept 2018

Abstract excerpt

Genomic instability is a hallmark feature of cancer cells, and can be caused by defective DNA repair, for instance due to inactivation of BRCA2 . Paradoxically, loss of Brca2 in mice results in embryonic lethality, whereas cancer cells can tolerate BRCA2 loss. This holds true for multiple DNA repair genes, and suggests that cancer cells are molecularly “rewired” to cope with defective DNA repair and the resulting...

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PMID: 30177840
DOI: 10.1038/s41388-018-0470-2

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