Article
Computational identification of mutator-derived lncRNA signatures of genome instability for improving the clinical outcome of cancers: a case study in breast cancer.
Briefings in bioinformatics - 25 Sept 2020
Bao Siqi, Zhao Hengqiang, Yuan Jian, Fan Dandan, Zhang Zicheng, Su Jianzhong, Zhou Meng
Abstract excerpt
Emerging evidence revealed the critical roles of long non-coding RNAs (lncRNAs) in maintaining genomic instability. However, identification of genome instability-associated lncRNAs and their clinical significance in cancers remain largely unexplored. Here, we developed a mutator hypothesis-derived computational frame combining lncRNA expression profiles and somatic mutation profiles in a tumor genome and...
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