A 12-Gene Genomic Instability Signature Predicts Clinical Outcomes in Multiple Cancer Types

Abstract excerpt

BACKGROUND AND AIMS: Genomic instability, as reflected in specific chromosomal aneuploidies and variation in the nuclear DNA content, is a defining feature of human carcinomas. It is solidly established that the degree of genomic instability influences clinical outcome. We have recently identified a 12-gene expression signature that discerned genomically stable from unstable breast carcinomas. This gene...

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