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Saturation Mutagenesis for Phenylalanine Ammonia Lyases of Enhanced Catalytic Properties.

Biomolecules - 30 May 2020

Tomoiagă Raluca Bianca, Tork Souad Diana, Horváth Ilka, Filip Alina, Nagy Levente Csaba, Bencze László Csaba

Abstract excerpt

Phenylalanine ammonia-lyases (PALs) are attractive biocatalysts for the stereoselective synthesis of non-natural phenylalanines. The rational design of PALs with extended substrate scope, highlighted the substrate specificity-modulator role of residue I460 of Petroselinum crispum PAL. Herein, saturation mutagenesis at key residue I460 was performed in order to identify PcPAL variants of enhanced activity or to...

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PMID: 32486192
DOI: 10.3390/biom10060838
PMCID: PMC7355458

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