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Article

The gene mutational discrepancies between primary and paired metastatic colorectal carcinoma detected by next-generation sequencing.

Journal of cancer research and clinical oncology - 1 Nov 2018

Zou Shuang-Mei, Li Wei-Hua, Wang Wen-Miao, Li Wen-Bin, Shi Su-Sheng, Ying Jian-Ming, Lyu Ning

Abstract excerpt

PURPOSE: To better understand the gene mutational status and heterogeneity between primary and metastatic CRC (mCRC) using a sensitive sequencing method. METHODS: The mutational status of EGFR, KRAS, NRAS, PIK3CA, ERBB2, BRAF, KIT, and PDGFRA was analyzed in 65 patients, with 147 samples of primary and paired live or lung metastatic CRC, using next-generation sequencing (NGS), quantitative RT-PCR (qPCR), and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 30171333
DOI: 10.1007/s00432-018-2742-1

Genes

BRAF
KRAS
NRAS
EGFR
ERBB2
KIT
PDGFRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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