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Article

KRAS discordance between primary and metastatic tumor in patients with metastatic colorectal carcinoma.

Journal of B.U.ON. : official journal of the Balkan Union of Oncology - 1 Jan 2000

Siyar Ekinci Ahmet, Demirci Umut, Cakmak Oksuzoglu Berna, Ozturk Ayse, Esbah Onur, Ozatli Tahsin, Celik Burcin, Budakoglu Burcin, Turker Ibrahim, Bal Oznur, Turan Nedim

Abstract excerpt

PURPOSE: Adding targeted therapies to chemotherapy in metastatic colorectal cancer (CRC) improves response rates and survival. KRAS is a predictive indicator for anti-epidermal growth factor receptor (EGFR) treatments. The most important reasons for KRAS discordance are intratumoral heterogeneity and incorrect mutation analysis. Evaluating the status of KRAS in primary and metastatic lesions becomes even more...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25778307

Genes

KRAS
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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