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Article

Targeted sequencing to identify novel genetic risk factors for deep vein thrombosis: a study of 734 genes.

Journal of thrombosis and haemostasis : JTH - 1 Dec 2018

de Haan H G, van Hylckama Vlieg A, Lotta L A, Gorski M M, Bucciarelli P, Martinelli I, Baglin T P, Peyvandi F, Rosendaal F R

Abstract excerpt

Essentials Deep vein thrombosis (DVT) has a large unknown genetic component. We sequenced coding areas of 734 hemostasis-related genes in 899 DVT patients and 599 controls. Variants in F5, FGA-FGG, CYP4V2-KLKB1-F11, and ABO were associated with DVT risk. Associations in KLKB1 and F5 suggest a more complex genetic architecture than previously thought. SUMMARY: Background Although several genetic risk factors for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Share to Sequence Analysis, DNA

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Source

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Identifiers

PMID: 30168256
DOI: 10.1111/jth.14279
PMCID: PMC6467059

Genes

KLKB1
ABO
FGA
FGG
MAF
CBS
MASP1

Provenance

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