Article
A genome-wide association study for venous thromboembolism: the extended cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium.
Genetic epidemiology - 1 Jul 2013
Tang Weihong, Teichert Martina, Chasman Daniel I, Heit John A, Morange Pierre-Emmanuel, Li Guo, Pankratz Nathan, Leebeek Frank W, Paré Guillaume, de Andrade Mariza, Tzourio Christophe, Psaty Bruce M, Basu Saonli, Ruiter Rikje, Rose Lynda, Armasu Sebastian M, Lumley Thomas, Heckbert Susan R, Uitterlinden André G, Lathrop Mark, Rice Kenneth M, Cushman Mary, Hofman Albert, Lambert Jean-Charles, Glazer Nicole L, Pankow James S, Witteman Jacqueline C, Amouyel Philippe, Bis Joshua C, Bovill Edwin G, Kong Xiaoxiao, Tracy Russell P, Boerwinkle Eric, Rotter Jerome I, Trégouët David-Alexandre, Loth Daan W, Stricker Bruno H Ch, Ridker Paul M, Folsom Aaron R, Smith Nicholas L
Abstract excerpt
Venous thromboembolism (VTE) is a common, heritable disease resulting in high rates of hospitalization and mortality. Yet few associations between VTE and genetic variants, all in the coagulation pathway, have been established. To identify additional genetic determinants of VTE, we conducted a two-stage genome-wide association study (GWAS) among individuals of European ancestry in the extended cohorts for heart...
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