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Article

Exploring genetic drivers of unexplained venous thromboembolism through whole-exome sequencing.

Thrombosis research - 1 Apr 2026

Mitic Martina Mia, Usjak Dusan, Kovac Mirjana, Basaric Dusica, Manevski Sofija Dunjic, Stikic Marija Cumbo, Vitkovac Aleksandra, Tomic Branko, Djordjevic Valentina

Abstract excerpt

Venous thromboembolism (VTE) is a complex multifactorial disorder in which the contribution of genetic and non-genetic risk factors is well recognized, yet standard thrombophilia testing is unable to explain a substantial proportion of cases. To explore additional genetic contributors, we performed whole-exome sequencing (WES) in 35 patients with recurrent and/or severe VTE in whom routine diagnostic evaluation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41831330
DOI: 10.1016/j.thromres.2026.109653

Genes

ADAMTS13
ARSA
F5
F7
FERMT3
LRP1
LRP5
MYH9
PLCG1
PROC
PROS1
STAB2
SVEP1
THBS1
TLN1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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