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Genome-wide association study of response to tumour necrosis factor inhibitor therapy in rheumatoid arthritis

29 Aug 2018

Abstract excerpt

Rheumatoid arthritis (RA) is characterised by chronic synovial joint inflammation. Treatment has been revolutionised by tumour necrosis factor alpha inhibitors (TNFi) but each available drug shows a significant non-response rate. We conducted a genome-wide association study of 1752 UK RA TNFi-treated patients to identify predictors of change in the Disease Activity Score 28 (DAS28) and subcomponents over 3–6...

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PMID: 30166627
DOI: 10.1038/s41397-018-0040-6

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