Article
Multiple polymerase gene mutations for human adaptation occurring in Asian H5N1 influenza virus clinical isolates.
Scientific reports - 30 Aug 2018
Arai Yasuha, Kawashita Norihito, Hotta Kozue, Hoang Phuong Vu Mai, Nguyen Hang Le Khanh, Nguyen Thach Co, Vuong Cuong Duc, Le Thanh Thi, Le Mai Thi Quynh, Soda Kosuke, Ibrahim Madiha S, Daidoji Tomo, Takagi Tatsuya, Shioda Tatsuo, Nakaya Takaaki, Ito Toshihiro, Hasebe Futoshi, Watanabe Yohei
Abstract excerpt
The role of the influenza virus polymerase complex in host range restriction has been well-studied and several host range determinants, such as the polymerase PB2-E627K and PB2-D701N mutations, have been identified. However, there may be additional, currently unknown, human adaptation polymerase mutations. Here, we used a database search of influenza virus H5N1 clade 1.1, clade 2.3.2.1 and clade 2.3.4 strains...
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