Article
Identification of mammalian-adapting mutations in the polymerase complex of an avian H5N1 influenza virus.
Nature communications - 17 Jun 2015
Taft Andrew S, Ozawa Makoto, Fitch Adam, Depasse Jay V, Halfmann Peter J, Hill-Batorski Lindsay, Hatta Masato, Friedrich Thomas C, Lopes Tiago J S, Maher Eileen A, Ghedin Elodie, Macken Catherine A, Neumann Gabriele, Kawaoka Yoshihiro
Abstract excerpt
Avian influenza viruses of the H5N1 subtype pose a serious global health threat due to the high mortality (>60%) associated with the disease caused by these viruses and the lack of protective antibodies to these viruses in the general population. The factors that enable avian H5N1 influenza viruses to replicate in humans are not completely understood. Here we use a high-throughput screening approach to identify...
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