Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Double mutations in the H9N2 avian influenza virus PB2 gene act cooperatively to increase viral host adaptation and replication for human infections.

The Journal of general virology - 1 Jun 2021

Elgendy Emad Mohamed, Arai Yasuha, Kawashita Norihito, Isobe Ayana, Daidoji Tomo, Ibrahim Madiha Salah, Ono Takao, Takagi Tatsuya, Nakaya Takaaki, Matsumoto Kazuhiko, Watanabe Yohei

Abstract excerpt

Avian H9N2 influenza viruses in East Asia are genetically diversified and multiple genotypes (A-W) have been established in poultry. Genotype S strains are currently the most prevalent strains, have caused many human infections and pose a public health threat. In this study, human adaptation mutations in the PB2 polymerase in genotype S strains were identified by database screening. Several PB2 double mutations...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Birds
Share to Influenza A Virus, H9N2 Subtype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Influenza, Human

Share to Influenza in Birds

Share to Orthomyxoviridae Infections

Share to Poultry

Share to Reassortant Viruses

Share to RNA-Dependent RNA Polymerase

Source

Identifiers

PMID: 34061017
DOI: 10.1099/jgv.0.001612

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Double mutations in the H9N2 avian influenza virus PB2 gene act cooperatively to increase viral host adaptation and replication for human infections.PMID 34061017Read ↗

Novel Polymerase Gene Mutations for Human Adaptation in Clinical Isolates of Avian H5N1 Influenza Viruses.Semantic proximity Read ↗

Genomic Signatures for Avian H7N9 Viruses Adapting to Humans.Semantic proximity Read ↗

PB2 mutations arising during H9N2 influenza evolution in the Middle East confer enhanced replication and growth in mammalsSemantic proximity Read ↗

PA Mutations Inherited during Viral Evolution Act Cooperatively To Increase Replication of Contemporary H5N1 Influenza Virus with an Expanded Host Range.Semantic proximity Read ↗

PB2-588 V promotes the mammalian adaptation of H10N8, H7N9 and H9N2 avian influenza virusesSemantic proximity Read ↗

The PB2 co‐adaptation of H10N8 avian influenza virus increases the pathogenicity to chickens and miceSemantic proximity Read ↗

Multiple polymerase gene mutations for human adaptation occurring in Asian H5N1 influenza virus clinical isolates.Semantic proximity Read ↗

The K526R substitution in viral protein PB2 enhances the effects of E627K on influenza virus replicationSemantic proximity Read ↗

The PB2 E627K mutation contributes to the high polymerase activity and enhanced replication of H7N9 influenza virusSemantic proximity Read ↗

V292I mutation in PB2 polymerase induces increased effects of E627K on influenza H7N9 virus replication in cells.Semantic proximity Read ↗

Prevailing I292V PB2 mutation in avian influenza H9N2 virus increases viral polymerase function and attenuates IFN-β induction in human cellsSemantic proximity Read ↗

Multiple Natural Substitutions in Avian Influenza A Virus PB2 Facilitate Efficient Replication in Human CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.