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Article

C-terminal domain of insulin-like growth factor (IGF) binding protein-6: structure and interaction with IGF-II.

Molecular endocrinology (Baltimore, Md.) - 1 Nov 2004

Headey Stephen J, Keizer David W, Yao Shenggen, Brasier Geoffrey, Kantharidis Phillip, Bach Leon A, Norton Raymond S

Abstract excerpt

IGFs are important mediators of growth. IGF binding proteins (IGFBPs) 1-6 regulate IGF actions and have IGF-independent actions. The C-terminal domains of IGFBPs contribute to high-affinity IGF binding and modulation of IGF actions and confer some IGF-independent properties, but understanding how they achieve this has been constrained by the lack of a three-dimensional structure. We therefore determined the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15308688
DOI: 10.1210/me.2004-0248

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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