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The DJ-1-derived peptide, ND-13, confers cardioprotection by inhibiting mitochondrial fission and preserving mitochondrial bioenergetics via the RhoA-ROCK1-Drp1 pathway

2024-06-28

Abstract excerpt

<h4>Background</h4> Acute myocardial infarction (AMI) and post-infarct heart failure (HF) are among the leading causes of death and disability worldwide. As such, new treatments are urgently needed to protect the heart against the detrimental effects of acute ischemia/reperfusion injury (IRI), in order to prevent the onset of HF and improve clinical outcomes following AMI. Given that mitochondrial dysfunction is...

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Identifiers and source

Literature Corpus work
94473d99-ab62-5eae-abdd-b80a090f6d90
DOI
10.1101/2024.06.24.600111
Open publication

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