Article

Genetic Variants that Modulate Alzheimer’s Disease Risk Deregulate Protein-Protein Correlations in the Gyrus Temporalis Medius

2025-02-14

Abstract excerpt

We conducted a comprehensive protein quantitative trait loci (pQTL) analysis on a unique set of Gyrus Temporalis Medius (GTM) samples obtained from 88 Alzheimer’s Disease (AD) patients, 53 non-demented individuals, and 49 cognitively healthy centenarians. This investigation revealed 8,081 genetic variants associated with the abundance of 227 proteins, including several novel variant-protein links not identified in...

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Literature Corpus work: ea287f96-1ba9-5fbe-a76e-02a6df596304
DOI: 10.1101/2025.02.11.25322052

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