Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Acetate-dependent tRNA acetylation required for decoding fidelity in protein synthesis.

Nature chemical biology - 1 Nov 2018

Taniguchi Takaaki, Miyauchi Kenjyo, Sakaguchi Yuriko, Yamashita Seisuke, Soma Akiko, Tomita Kozo, Suzuki Tsutomu

Abstract excerpt

Modification of tRNA anticodons plays a critical role in ensuring accurate translation. N4-acetylcytidine (ac4C) is present at the anticodon first position (position 34) of bacterial elongator tRNAMet. Herein, we identified Bacillus subtilis ylbM (renamed tmcAL) as a novel gene responsible for ac4C34 formation. Unlike general acetyltransferases that use acetyl-CoA, TmcAL activates an acetate ion to form...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetates
Share to Adenosine Triphosphate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bacillus subtilis

Share to Catalysis

Share to Codon, Terminator

Share to Mycoplasma

Share to Protein Domains

Share to RNA, Transfer

Source

Identifiers

PMID: 30150682
DOI: 10.1038/s41589-018-0119-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Acetate-dependent tRNA acetylation required for decoding fidelity in protein synthesis.PMID 30150682Read ↗

The RNA acetyltransferase driven by ATP hydrolysis synthesizes N4-acetylcytidine of tRNA anticodon.Semantic proximity Read ↗

Methylated nucleosides in tRNA and tRNA methyltransferasesSemantic proximity Read ↗

Molecular basis for t6A modification in human mitochondria.Semantic proximity Read ↗

Activity reconstitution of Kre33 and Tan1 reveals a molecular ruler mechanism in eukaryotic tRNA acetylation.Semantic proximity Read ↗

Substrate specificities of Escherichia coli ItaT that acetylates aminoacyl-tRNAs.Semantic proximity Read ↗

Gcn4 misregulation reveals a direct role for the evolutionary conserved EKC/KEOPS in the t6A modification of tRNAs.Semantic proximity Read ↗

Anticodon sequence determines the impact of mistranslating tRNA <sup>Ala</sup> variantsSemantic proximity Read ↗

Identification of 2-methylthio cyclic N6-threonylcarbamoyladenosine (ms2ct6A) as a novel RNA modification at position 37 of tRNAs.Semantic proximity Read ↗

Paradox of mistranslation of serine for alanine caused by AlaRS recognition dilemma.Semantic proximity Read ↗

Translational fidelity maintenance preventing Ser mis-incorporation at Thr codon in protein from eukaryote.Semantic proximity Read ↗

Eukaryotic AlaX provides multiple checkpoints for quality and quantity of aminoacyl-tRNAs in translationSemantic proximity Read ↗

Loss of Elongator- and KEOPS-Dependent tRNA Modifications Leads to Severe Growth Phenotypes and Protein Aggregation in Yeast.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.