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Article

Translational fidelity maintenance preventing Ser mis-incorporation at Thr codon in protein from eukaryote.

Nucleic acids research - 7 Jan 2013

Zhou Xiao-Long, Ruan Zhi-Rong, Huang Qian, Tan Min, Wang En-Duo

Abstract excerpt

Aminoacyl-tRNA synthetase (aaRS) catalyzes the first step of protein synthesis, producing aminoacyl-tRNAs as building blocks. Eukaryotic aaRS differs from its prokaryotic counterpart in terminal extension or insertion. Moreover, the editing function of aaRSs is an indispensable checkpoint excluding non-cognate amino acids at a given codon and ensuring overall translational fidelity. We found higher eukaryotes...

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Identifiers

PMID: 23093606
DOI: 10.1093/nar/gks982
PMCID: PMC3592468

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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