Article
Identification of 2-methylthio cyclic N6-threonylcarbamoyladenosine (ms2ct6A) as a novel RNA modification at position 37 of tRNAs.
Nucleic acids research - 28 Feb 2017
Kang Byeong-Il, Miyauchi Kenjyo, Matuszewski Michal, D'Almeida Gabriel Silveira, Rubio Mary Anne T, Alfonzo Juan D, Inoue Kazuki, Sakaguchi Yuriko, Suzuki Takeo, Sochacka Elzbieta, Suzuki Tsutomu
Abstract excerpt
Transfer RNA modifications play pivotal roles in protein synthesis. N6-threonylcarbamoyladenosine (t6A) and its derivatives are modifications found at position 37, 3΄-adjacent to the anticodon, in tRNAs responsible for ANN codons. These modifications are universally conserved in all domains of life. t6A and its derivatives have pleiotropic functions in protein synthesis including aminoacylation, decoding and...
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