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Article

Gcn4 misregulation reveals a direct role for the evolutionary conserved EKC/KEOPS in the t6A modification of tRNAs.

Nucleic acids research - 1 Aug 2011

Daugeron Marie-Claire, Lenstra Tineke L, Frizzarin Martina, El Yacoubi Basma, Liu Xipeng, Baudin-Baillieu Agnès, Lijnzaad Philip, Decourty Laurence, Saveanu Cosmin, Jacquier Alain, Holstege Frank C P, de Crécy-Lagard Valérie, van Tilbeurgh Herman, Libri Domenico

Abstract excerpt

The EKC/KEOPS complex is universally conserved in Archaea and Eukarya and has been implicated in several cellular processes, including transcription, telomere homeostasis and genomic instability. However, the molecular function of the complex has remained elusive so far. We analyzed the transcriptome of EKC/KEOPS mutants and observed a specific profile that is highly enriched in targets of the Gcn4p...

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Identifiers

PMID: 21459853
DOI: 10.1093/nar/gkr178
PMCID: PMC3152333

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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