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Article

Substrate specificities of Escherichia coli ItaT that acetylates aminoacyl-tRNAs.

Nucleic acids research - 27 Jul 2020

Zhang Chuqiao, Yashiro Yuka, Sakaguchi Yuriko, Suzuki Tsutomu, Tomita Kozo

Abstract excerpt

Escherichia coli ItaT toxin reportedly acetylates the α-amino group of the aminoacyl-moiety of Ile-tRNAIle specifically, using acetyl-CoA as an acetyl donor, thereby inhibiting protein synthesis. The mechanism of the substrate specificity of ItaT had remained elusive. Here, we present functional and structural analyses of E. coli ItaT, which revealed the mechanism of ItaT recognition of specific aminoacyl-tRNAs...

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Identifiers

PMID: 32501503
DOI: 10.1093/nar/gkaa487
PMCID: PMC7367177

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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