Article
The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America - 7 Oct 2008
Thomas Elizabeth A, Coppola Giovanni, Desplats Paula A, Tang Bin, Soragni Elisabetta, Burnett Ryan, Gao Fuying, Fitzgerald Kelsey M, Borok Jenna F, Herman David, Geschwind Daniel H, Gottesfeld Joel M
Abstract excerpt
Transcriptional dysregulation has emerged as a core pathologic feature of Huntington's disease (HD), one of several triplet-repeat disorders characterized by movement deficits and cognitive dysfunction. Although the mechanisms contributing to the gene expression deficits remain unknown, therapeutic strategies have aimed to improve transcriptional output via modulation of chromatin structure. Recent studies have...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.