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Article

PBRM1 and VHL expression correlate in human clear cell renal cell carcinoma with differential association with patient's overall survival.

Urologic oncology - 1 Mar 2018

Högner Anica, Krause Hans, Jandrig Burkhard, Kasim Mumtaz, Fuller Tom Florian, Schostak Martin, Erbersdobler Andreas, Patzak Andreas, Kilic Ergin

Abstract excerpt

OBJECTIVE: To identify the clinicopathological association of PBRM1 (Polybromo-1 gene) and VHL (von Hippel-Lindau gene) expression at mRNA and protein levels in clear cell renal cell carcinoma (ccRCC) and its role in tumor progression. PATIENTS AND METHODS: Immunohistochemical analysis, Western blotting and qPCR analysis of PBRM1 and VHL were performed on fresh-frozen ccRCC and adjacent normal tissue obtained...

Topics

Aged
Carcinoma, Renal Cell
DNA-Binding Proteins
Disease Progression
Down-Regulation
Female
Follow-Up Studies
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Kidney

Kidney Neoplasms

Male

Middle Aged

Mutation

Neoplasm Grading

Neoplasm Staging

Nephrectomy

Source

Identifiers

PMID: 29169846
DOI: 10.1016/j.urolonc.2017.10.027

Genes

VHL
PBRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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