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Article

Receptor CD36 links a risk-associated allele to obesity and metabolic disorders.

The Journal of biological chemistry - 24 Aug 2018

Liu Min, Tso Patrick, Woods Stephen C

Abstract excerpt

Mice harboring a particular allele of the human brain-derived neurotropic factor (BDNFM/M mice) develop extreme obesity and insulin resistance when fed a high-fat diet. The underlying mechanisms of this genetic risk factor for obesity are unclear. In the current issue of JBC, Yang et al. report that pharmacological inhibition of integral membrane protein CD36 significantly reduces body weight gain and improves...

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Identifiers

PMID: 30143599
DOI: 10.1074/jbc.H118.004818
PMCID: PMC6109921

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