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Article

Inhibition of the CD36 receptor reduces visceral fat accumulation and improves insulin resistance in obese mice carrying the BDNF-Val66Met variant.

The Journal of biological chemistry - 24 Aug 2018

Yang Jiwon, Park Keun Woo, Cho Sunghee

Abstract excerpt

Obesity-induced metabolic dysfunctions increase the risk for vascular diseases, including type II diabetes and stroke. Managing obesity is of interest to address the worldwide health problem; however, the role of genetic variability in human obesity development and specific targets for obesity-related metabolic disease have not been thoroughly studied. A SNP in the brain-derived neurotropic factor (BDNF) gene...

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Identifiers

PMID: 29914985
DOI: 10.1074/jbc.RA118.002405
PMCID: PMC6109932

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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Inhibition of the CD36 receptor reduces visceral fat accumulation and improves insulin resistance in obese mice carrying the BDNF-Val66Met variant.PMID 29914985Read ↗

Receptor CD36 links a risk-associated allele to obesity and metabolic disorders.Semantic proximity Read ↗

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Genetic variant of BDNF (Val66Met) polymorphism attenuates stroke-induced angiogenic responses by enhancing anti-angiogenic mediator CD36 expression.Semantic proximity Read ↗

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