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Article

OPRD1 gene affects disease vulnerability and environmental stress in patients with heroin dependence in Han Chinese.

Progress in neuro-psychopharmacology & biological psychiatry - 8 Mar 2019

Huang Chang-Chih, Kuo Shin-Chang, Yeh Ta-Chuan, Yeh Yi-Wei, Chen Chun-Yen, Liang Chih-Sung, Tsou Chang-Chih, Lin Chun-Long, Ho Pei-Shen, Huang San-Yuan

Abstract excerpt

Exposure to stress not only increases the vulnerability to heroin dependence (HD) but also provokes relapse. The etiology of HD and the role of life stress remain unclear, but prior studies suggested that both genetic and environmental factors are important. Opioid related genes, including OPRM1, OPRD1, OPRK1, and POMC, are obvious candidates for HD. Therefore, this study was conducted to explore whether the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 30171993
DOI: 10.1016/j.pnpbp.2018.08.028

Genes

OPRD1
OPRK1
OPRM1
POMC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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