Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Thymosin beta4 inhibits TNF-alpha-induced NF-kappaB activation, IL-8 expression, and the sensitizing effects by its partners PINCH-1 and ILK.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jun 2011

Qiu Ping, Wheater Michelle Kurpakus, Qiu Yue, Sosne Gabriel

Abstract excerpt

The mechanisms by which thymosin β 4 (Tβ(4)) regulates the inflammatory response to injury are poorly understood. Previously, we demonstrated that ectopic Tβ(4) treatment inhibits injury-induced proinflammatory cytokine and chemokine production. We have also shown that Tβ(4) suppresses TNF-α-mediated NF-κB activation. Herein, we present novel evidence that Tβ(4) directly targets the NF-κB RelA/p65 subunit. We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actins
Share to Anti-Inflammatory Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chlorocebus aethiops

Share to COS Cells

Share to Interleukin-8

Share to LIM Domain Proteins

Share to NF-kappa B

Share to Transcription Factor RelA

Source

Open in PubMed Open full text

Identifiers

PMID: 21343177
DOI: 10.1096/fj.10-167940
PMCID: PMC3101037

Genes

TNF
ILK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Thymosin beta4 inhibits TNF-alpha-induced NF-kappaB activation, IL-8 expression, and the sensitizing effects by its partners PINCH-1 and ILK.PMID 21343177Read ↗

Advances in Thymosin β10 Research: Differential Expression, Molecular Mechanisms, and Clinical Implications in Cancer and Other ConditionsSemantic proximity Read ↗

OTULIN in NF-κB signaling, cell death, and diseaseSemantic proximity Read ↗

TRAF4 functions as an intermediate of GITR-induced NF-kappaB activation.Semantic proximity Read ↗

N4BP1 negatively regulates NF-κB by binding and inhibiting NEMO oligomerization.Semantic proximity Read ↗

Polyubiquitination of transforming growth factor β (TGFβ)-associated kinase 1 mediates nuclear factor-κB activation in response to different inflammatory stimuli.Semantic proximity Read ↗

Betulinic Acid Promotes Motor Function Recovery after Spinal Cord Injury by Inhibiting Apoptosis through Myc/NF-κB Signaling PathwaySemantic proximity Read ↗

Modulation of the functional binding sites for TGF-beta on the type II receptor leads to suppression of TGF-beta signaling.Semantic proximity Read ↗

The TAB1-p38α complex aggravates myocardial injury and can be targeted by small molecules.Semantic proximity Read ↗

Zanubrutinib ameliorates experimental idiopathic inflammatory myopathy-associated interstitial lung disease by BTK/NF-κB signaling pathwaySemantic proximity Read ↗

Twist regulates cytokine gene expression through a negative feedback loop that represses NF-kappaB activity.Semantic proximity Read ↗

Epithelial transforming growth factor β-activated kinase 1 (TAK1) is activated through two independent mechanisms and regulates reactive oxygen species.Semantic proximity Read ↗

TWEAK and cIAP1 regulate myoblast fusion through the noncanonical NF-κB signaling pathway.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.