A novel lipid binding site formed by the MAP kinase insert in p38 alpha.

doi:10.1016/j.jmb.2007.09.002

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Article

A novel lipid binding site formed by the MAP kinase insert in p38 alpha.

Journal of molecular biology - 4 Jan 2008

Diskin Ron, Engelberg David, Livnah Oded

Abstract excerpt

The p38 mitogen-activated protein (MAP) kinases function as signaling molecules essential for many cellular processes, particularly mediating stress response. The activity of p38 MAP kinases is meticulously regulated to reach the desired cellular phenotype. Several alternative activation and attenuation mechanisms have been characterized recently which include new phosphorylation sites. Here we present the...

Topics

Arachidonic Acid
Binding Sites
Chromatography, Gel
Computer Simulation
Crystallography, X-Ray
Detergents
Enzyme Activation
Glucosides
Humans
Isoenzymes
Kinetics
Models, Chemical

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Models, Molecular

Mutation

Oxidation-Reduction

Phosphorylation

Protein Binding

Protein Conformation

Source

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Identifiers

PMID: 17999933
DOI: 10.1016/j.jmb.2007.09.002

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