Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeting the Tyrosine Kinase 2 (TYK2) Pseudokinase Domain: Discovery of the Selective TYK2 Inhibitor ABBV-712

12 Oct 2023

Abstract excerpt

Tyrosine kinase 2 (TYK2) is a nonreceptor tyrosine kinase that belongs to the JAK family also comprising JAK1, JAK2, and JAK3. TYK2 is an attractive target for various autoimmune diseases as it regulates signal transduction downstream of IL-23 and IL-12 receptors. Selective TYK2 inhibition offers a differentiated clinical profile compared to currently approved JAK inhibitors. However, selectivity for TYK2 versus...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytokine Signaling Pathways and Interactions
Share to Mast cells and histamine
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37823891
DOI: 10.1021/acs.jmedchem.3c01373

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeting the Tyrosine Kinase 2 (TYK2) Pseudokinase Domain: Discovery of the Selective TYK2 Inhibitor ABBV-712PMID 37823891Read ↗

Selective TYK2 inhibitors as potential therapeutic agents: a patent review (2019–2021)Semantic proximity Read ↗

Therapeutic potential of tyrosine kinase 2 in autoimmunity.Semantic proximity Read ↗

Tyk2 Targeting in Immune-Mediated Inflammatory DiseasesSemantic proximity Read ↗

Structure of the pseudokinase-kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition.Semantic proximity Read ↗

A Restricted Role for TYK2 Catalytic Activity in Human Cytokine Responses Revealed by Novel TYK2-Selective InhibitorsSemantic proximity Read ↗

Tyrosine kinase 2 (TYK2) in cytokine signalling and host immunitySemantic proximity Read ↗

TYK2: An Upstream Kinase of STATs in CancerSemantic proximity Read ↗

Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphomaSemantic proximity Read ↗

TYK2 in Cancer Metastases: Genomic and Proteomic DiscoverySemantic proximity Read ↗

Structural and Functional Characterization of the JH2 Pseudokinase Domain of JAK Family Tyrosine Kinase 2 (TYK2).Semantic proximity Read ↗

A novel mutation causing complete TYK2 deficiency, with severe respiratory viral infections, EBV-driven lymphoma, and Jamestown Canyon viral encephalitisSemantic proximity Read ↗

Insight into Janus kinases specificity: From molecular architecture to cancer therapeuticsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.