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Article

Genetic correlations between nicotine reinforcement-related behaviors and propensity toward high or low alcohol preference in two replicate mouse lines.

Genes, brain, and behavior - 1 Mar 2019

Weera Marcus M, Agim Zeynep S, Cannon Jason R, Chester Julia A

Abstract excerpt

Common genetic factors may contribute to the high comorbidity between tobacco smoking and alcohol use disorder. Here, we assessed behavioral and biological effects of nicotine in replicate mouse lines selectively bred for high (HAP2/3) or low alcohol preference (LAP2/3). In Experiment 1, free-choice (FC) oral nicotine and quinine intake were assessed in HAP2/3 and LAP2/3 mice. Effects of nicotinic acetylcholine...

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Identifiers

PMID: 30129253
DOI: 10.1111/gbb.12515
PMCID: PMC6384161

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