Article
Genome-wide RNAi Screen Identifies Cohesin Genes as Modifiers of Renewal and Differentiation in Human HSCs.
Cell reports - 29 Mar 2016
Galeev Roman, Baudet Aurélie, Kumar Praveen, Rundberg Nilsson Alexandra, Nilsson Björn, Soneji Shamit, Törngren Therese, Borg Åke, Kvist Anders, Larsson Jonas
Abstract excerpt
To gain insights into the regulatory mechanisms of hematopoietic stem cells (HSCs), we employed a genome-wide RNAi screen in human cord-blood derived cells and identified candidate genes whose knockdown maintained the HSC phenotype during culture. A striking finding was the identification of members of the cohesin complex (STAG2, RAD21, STAG1, and SMC3) among the top 20 genes from the screen. Upon individual...
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