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Article

Interleukin-6 deletion stimulates revascularization and new bone formation following ischemic osteonecrosis in a murine model.

Bone - 1 Nov 2018

Kuroyanagi Gen, Adapala Naga Suresh, Yamaguchi Ryosuke, Kamiya Nobuhiro, Deng Zhuo, Aruwajoye Olumide, Kutschke Michael, Chen Elena, Jo Chanhee, Ren Yinshi, Kim Harry K W

Abstract excerpt

Legg-Calvé-Perthes disease (LCPD) is a childhood form of ischemic osteonecrosis of the femoral head which can produce a permanent femoral head deformity and early osteoarthritis. The femoral head deformity results from increased bone resorption and decreased bone formation during repair and remodeling of the necrotic femoral head. A recent study showed that a pro-inflammatory cytokine, interleukin-6 (IL-6), is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30125727
DOI: 10.1016/j.bone.2018.08.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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